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NF-kB在神经元变性中的作用 被引量：3

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摘要 细胞核因子kB(Nuclear Factor-kB,NF-kB)是1986年由Sen和Baitirmore首先描述,是一种B细胞核因子,可与免疫球蛋白的轻链(k链)增强子结合并具有结构性转录激活活性,故命名为细胞核因子或称k基因核因子.随着研究的进一步深入,发现NF-kB是一类普遍存在的细胞转录因子,在其它细胞中也有表达[1].它调控着编码细胞因子、生长因子、细胞粘附分子和一些在健康和疾病状态下的急性蛋白因子.
作者 陶陆阳 陈溪萍 丁梅 官大威
机构地区 中国医科大学法医学院
出处 《中国法医学杂志》 CSCD 2002年第2期126-128,共3页 Chinese Journal of Forensic Medicine
关键词 NF-KB 神经元凋亡 海马神经元
分类号 D919 [医药卫生—法医学]
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参考文献20

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  • 2[2]Chen F,Castranova V,Shi XL,et al.New insights into the role of nuclear factor-kB,an ubiquitoustranscription factor in the initiation of diseases [J].Clin Chem,1999,45:7
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同被引文献51

  • 1赵全如,谢晓燕.丹参的化学成分及药理作用研究进展[J].广东化工,2021(1):57-59. 被引量：75
  • 2Toliver-Kinsky T, Rassin D, Perez-Polo JR. NF-kappaB activity decreases in basal forebrain of young and aged rats aider hyperoxia [J]. Neurobiol Aging, 2002, 23(5): 899-905.
  • 3Gu Z, Wortwein G, Yu J, et al. Model for aging in the basal forebrain cholinergic system[J]. Antioxid Redox Signal, 2000, 2(3): 437-447.
  • 4Li F, Chong ZZ, Maiese K. Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB[J]. Curr Neurovasc Res, 2006, 3(3): 187-201,
  • 5Ravati A, Ahlemeyer B, Becker A, et al. Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB [J]. J Neurochem, 2001,78(4): 909-919.
  • 6Caccamo D, Campisi A, Marini H, et al. Glutamate promotes NF-kappaB pathway in primary astrocytes: protective effects of IRFI016, a synthetic vitamin E analogue[J]. Exp Neurol, 2005, 193 (2): 377-383.
  • 7Pizzi M, Sarnico I, Boroni F, et al. NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity[J]. Cell Death Differ, 2005, 12(7): 761-772.
  • 8Zhang W, Stanimirovic D. Current and future therapeutic strategies to target inflammation in stroke [J]. Curt Drug Targets Inflamm Allergy, 2002, 1(2): 151-166.
  • 9Daily D, Vlamis-Gardikas A, Often D, et al. Glutaredoxin Protects Cerebellar Granule Neurons flom Dopamine-induced Apoptosis by Activating NF-κB via Ref-1 [J]. J Biol Chem, 2001, 276 (2): 1335-1344.
  • 10Kaltschmidt B, Widera D. Kaltschmidt C. Signaling via NF-kappaB in the nervous system[J]. Biochim Biophys Acta, 2005, 1745(3): 287-299.

引证文献3

二级引证文献6

中国法医学杂志
2002年 第2期

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