联合紫杉醇化疗晚期恶性肿瘤24例

Combined Chemotherapy of Paclitaxel and Others for 24 Patients with Malignant Tumor

目的 :评价联合紫杉醇化疗晚期恶性肿瘤的疗效。方法 :观察对象为肺癌 10例 ,乳腺癌 8例 ,卵巢癌 5例 ,鼻咽癌 1例。联合化疗方案中紫杉醇 135mg/m2 ,静滴 3小时 ,4周 1个疗程 ,共 2～ 3周期 ,其它药物为卡铂、吡柔比星等。结果 :总有效率 71% ,不良反应主要为骨髓抑制、脱发、恶心、呕吐。结论 :联合紫杉醇化疗肺癌、乳腺癌、卵巢癌等疗效确切 。

Objective:To evaluate the effcicacy of Pactitaxel on advanced malignant tumor.Methods:To observe 10 cases with lung cancer,8 casese with breast cancer,5 cases with ovarian cancer and 1 case with nasopharyngeal carcinoma.24 patients were treated by combination chemotherapy of pactitaxel 135mg/m 2,combined with carboplatin or pirarubin was given intravenously for three hours.Each vegimen included 2 to 3 cycle and it was repeated every four weeks.Result:A total response rate for 24 patients was 71%.The major side effects wree tolerable antitumor agent in treatment of lung cancer,breast cancer or ovarian cancer.