介入传导液治疗慢性非特异性溃疡性结肠炎的研究

Clinical study of Jieruchuandaoye on the chronic nonspecific ulcerative colitis

目的 :研究中药介入传导液治疗溃疡性结肠炎的疗效和安全性。方法 :中药介入传导液全结肠给药治疗溃疡性结肠炎 89例 ,以 SA SP为对照 ,观察临床症状、结肠粘膜炎症、淋巴细胞转化率、血浆蛋白含量、血浆免疫复合物含量的变化情况。结果 :介入传导液可以明显改善溃疡性结肠炎患者的临床症状及结肠粘膜炎症反应 ,降低血浆免疫复合物含量 ,提高淋巴细胞转化率及血浆蛋白含量。在治愈率、总有效率上 ,介入传导液 ( 84.5 % ,97.2 % )明显高于 SA SP( 13.4% ,43.3% ) ( P<0 .0 5 ) ,且无明显副作用。结论 :中药介入传导液是一种高效、安全的治疗溃疡性结肠炎的灌肠药物。

Objective: It is to investigate the effect and safety of Jieruchuandaoye (JRCDY) on the chronic nonspecific ulcerative colitis (UC). Methods: Eighty-nine UC patients were treated with JRCDY by all-colon administration. Being contrasted with SASP, clinical symptoms, the inflammation of colonic mucosa, LTR, TP, and CIC were assessed. Results: JRCDY could evidently improve clinical symptoms and the inflammation of colonic mucosa, diminish CIC and increase LTR and TP. On the rate of cure and the total rate of effect, JRCDY (84.5%, 97.2%) was superior to SASP (13.4%, 43.3%)( P<0.05 ), and JRCDY had no side effects. Conclusion: JRCDY is a very effective and safe enema for UC.