肠道病毒与小儿髋关节滑膜炎病因的研究

A study on relationship between juvenile transient synovitis and enterovirus

目的 研究小儿髋关节滑膜炎与肠道病毒 ,特别是柯萨奇 B组病毒 (coxsarievivusCVB)感染的关系。方法 采用酶联免疫吸附试验 (EL ISA法 )对 16 2例小儿髋关节滑膜炎患儿静脉血和其中的 2 1例关节腔液进行特异性病毒 Ig M抗体检测 ,CVB阳性者进行血清学分型及病毒分离。结果 在 16 2例静脉血样本中特异性 Ig M阳性 6 2例 ,占总检数的 38.2 7% ,CVB- Ig M2 6例占 16 .0 5 % ,腺病毒 (adenovirus,Ad V) - Ig M19例占 11.73% ,巨细胞病毒 (cytomegalovirus,CMV)- Ig M10例占 6 .17% ,呼吸道合胞病毒 (respiratory syncytial virus,RSV) - Ig M4例占 2 .47% ;在关节腔液中检出 9例 CVB阳性 ,血清学分型 8例为 CVB3,1例为 CVB4,并分离出 1例 CVB3。结论 CVB是小儿髋关节滑膜炎感染的主要病毒 ,而且以

Objective To study the relationship between juvenile transient synovitis of the hip and enterovirus.Methods EV-IgM antibody was detected with ELISA in blood and arthrocentesis. At same time, sample with coxsackievirus B(CVB) IgM positive was tested by serptype.Results IgM antibody was detected in 38.27% in blood of the patients and in 76.19% in arthrocentesis.CVB-IgM was found positive in 16.05% of blood and in 42.86% of arthrocentesis.AdV-IgM was in 11.73% and in 23.81%,respectively.Most of the CVB-IgM positive individuals were infected with CVB3.Conclusion The results of this study suggest that there may be a significant correlation between juvenile transient synovitis and CVB, especially CVB3.