不同性质腹水中sIL-2R和CEA水平的变化

Changes between the levels of soluble interleukin-2 receptor and carcinoembryonic antigen in different ascites

目的 :研究白细胞介素 2受体 (sIL 2R)和癌胚抗原 (CEA)在各种类型腹水中的变化。方法 :用双抗体夹心酶联免疫吸附法测定 2 8例腹腔漏出液、2 1例腹腔炎性渗出液、2 9例癌性腹水中可溶性白介素 2受体 ,同时用放免法测定其癌胚抗原的变化。结果 :渗出性与癌性腹水中sIL 2R值明显高于漏出液腹水值 ,但前二者间差别不明显 ;癌性腹水中CEA值明显高于漏出液及渗出液腹水值 ,但后二者差别不明显。结论 :联合测定腹水中sIL

Objective:To study the changes of soluble interleukin 2 receptor (sIL 2R) and carcinoembryonic antigen (CEA) in all types of ascites. Methods:Soluble interleukin 2 receptors were determined by double antibody sandwich enzyme linked immunosorbent assay (DAS ELISA) for carcinoembryonic antigen in 28 transudate, 21 effusion and 29 carcinomatous ascites. At the same time, radioimmunoassay was used to measure the changes of carcinoembryonic antigen. Results:sIL 2R in exudative ascites and carcinomatous hydroperitoneum was significantly higher than that in transudate ascites, but there was no significant difference between inflammatory exudate and carcinomatous hydroperitoneum. CEA in carcinomatous hydroperitoneum was significantly higher than that in transudate ascites and inflammatory exudate, but there was no significant difference. Conclusion:The combined measurement of sIL 2R and CEA is helpful in differentiating carcinomatous hydroperitoneum, transudate ascites and inflammatory exudates.