住院精神分裂症患者使用苯二氮(艹卓)类药物的调查

A survey of administration of benzodiazepines in schizophrenic inpatients

目的 探讨住院精神分裂症合并使用苯二氮(艹卓)类药物(BZD)的合理性、依赖性及其增效作用,评价苯二氮(艹卓)类药物依赖自评量表(BDEPQ)对精神分裂症病人诊断BAD依赖的价值。方法 调查住院≥2月,诊断为精神分裂症,其中合并使用BAD≥1月,用BDEPQ量表评分,对评分在24～39分者停药1周观察。用ICD-10药物依赖的诊断标准再诊断。结果 精神分裂症病人合并使用BZD为41.4％,发生依赖为8.5％,BDEPQ评分≥34分作为评定依赖的划界分与ICD-10诊断一致性较高,合并使用BZD可减少抗精神病药物(APD)用量,而疗效相同。结论 BDEPQ是BZD依赖较好的筛查工具,住院精神分裂症病人长期使用BZD是不合理的,本组BZD依赖与药物剂量及用药时间无关。

Objectives: To study the rationality, dependence and symergism of combined administration of benzodiazepines (BZD) in inpatients with schizophrenia. Method: The patients who were hospitalized for more than 2 months and co-teated with BDEPQ for over 1 month were evaluated with BDEPQ. Those who scored 24 -39 in BDEPQ were rediagnosed with the crieteria of International Classification of Disease (ICD)-10 for drug dependence. Results: The rate of combined BZD administration was 41.4%, 8.5% resulting in drug dependence. 34 scores was regarded as diagnostic criteria for drug dependence, which was highly consistent with ICD-10. Conclusion: It is unreasonable for inpatients with schizophrenia to be treated with BZD for a long time.