摘要
目的与方法:本文研究乙酰氨基己酸锌对小鼠的急性毒性作用以及用鼠伤寒沙门氏菌突变株的回复突变性检测乙酰氨基己酸锌是否具有致突变性。结果与讨论:结果表明,乙酰氨基己酸锌的小鼠腹腔注射的半数致死量LD50=364.69mg/kg;在加与不加S9的条件下,对TA97,TA98,TA100和TA102的致突变作用为阴性。
Objective and Methods:The acute toxicity of mice and mutagenesis(Ames assay)of ZAC were evaluated.Results and Conclusion:Median lethal dosage of the ZAC in mice was364.69mg?kg by inpouring admistration(i.p.).The mutagenesis was not observed in TA97,TA98,TA100and TA102,with or without a mammalian S9activition component.
出处
《哈尔滨商业大学学报(自然科学版)》
CAS
2002年第1期25-29,共5页
Journal of Harbin University of Commerce:Natural Sciences Edition
关键词
急性毒性
致突变
acute toxicity
mutagenesis