人参茎叶皂甙、人参根皂甙抗抑郁作用研究

Study on antidepressant-like effect of ginseng stems and leaves saponins(GSLS)and ginseng roofs sapmins(GRS)

目的 观察人参茎叶皂甙和人参根甙的抗抑郁作用。方法 采用大鼠强迫游泳实验的方法。结果 人参茎叶皂甙和根皂甙的低剂量组 (5 0mg/kg)和高剂量组 (2 0 0mg/kg)均能明显缩短强迫游泳大鼠的不动时间。

Objective To study the antidepressant-like effect of the ginseng stems and leaves saponins(GSLS)and ginseng roots saponins(GRS).Method The method of rats forced-swimming test was abopted to study the antidepressant-like effect.Result The lower and higher dose of GSLS and GRS both could suppress significantly the accumulated immobility time of rats forced-swimming.Conclusion GSLS and GRS possesses antidepressant-like effect.