摘要
目的:观察木芙蓉叶有效部位(MFR-C)的抗炎与镇痛药效学结果。方法:以盐酸青藤碱组和空白组为对照,口服灌胃不同剂量 MFR-C,分别进行小鼠腹腔毛细血管通透性实验、小鼠耳肿胀实验及小鼠扭体实验。结果:。(1)MFR-C 抑制小鼠腹腔毛细血管通透率为30.4%,与空白对照组比较,抑制渗出作用差异有显著性(P<0.05);(2)小鼠耳肿胀实验显示 MFR-C 有抑制二甲苯造成的非特异性耳肿胀的作用,与空白对照组比较,差异有显著性(P<0.05),与盐酸青藤碱组作用相似;(3)MFR-C 具有镇痛作用,可减少小鼠扭体数,与空白对照组比较,差异有显著性(P<0.05)。结论:MFR-C 具有良好的抗炎与镇痛作用。
Objective:To observe the anti-inflammatory and analgesic effect of MFR-C(sinomonine) ,an active fraction of Folium Hibisus mu- tabilis.Methods:Mice were treated with different doses of MFR-C by gastric infusion for 5 days,then the peritoneal capillary permeabil- ity test,ear swelling test and twist test were performed in the mice.The data obtained were compared with those obtained in the blank control groups and the positive control group (voltaren treated).Results:Capillary permeability inhibition rate of ...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第S1期222-224,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
本课题为上海市教委资助重点课题(No.98zd33)
关键词
木芙蓉叶
有效部位
抗炎
镇痛
毛细血管通透性
扭体实验
Folium Hibisus mutabilis
active fraction
anti-inflammation
analgesia
capillary permeability
twist test
