参麦活血饮对糖尿病大鼠周围神经传导速度及血浆内皮素水平的影响

Effects of Shenmai Huoxue Decoction on Peripheral Nerve Conduction Velocity and Plasma Endothelin Livel in Diabetic Rats

目的:观察参麦活血饮对糖尿病大鼠周围神经传导速度及血浆内皮素(ET)水平的影响,并探讨其作用的可能机理。方法:采用链脲佐菌素(STZ)诱发糖尿病大鼠模型,造模1周后用参麦活血饮治疗。用药4周后用诱发肌电图测定坐骨神经的运动神经传导速度(MNCV),近尾部神经的感觉神经传导速度(SNCV)和 H 反射,放射免疫方法测定血浆 ET 水平。结果:糖尿病大鼠周围神经传导速度减慢,H 反射延迟,血浆 ET 水平升高,与正常对照组比较,差异有显著性(P<0.05),参麦活血饮治疗组上述改变减轻,与糖尿病模型组比较,差异有显著性(P<0.05)。结论:参麦活血饮可明显缓解糖尿病大鼠周围神经的早期病变。

Objective:To observe the effects of Shenmai Huoxue Decoction(SMHX)on peripheral motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV)endothelin(ET)level in plasma in diabetic rats,and explore the possible mechanism. Methods:The model diabetic rats were induced by streptozotocin(STZ),1 week after STZ injection the diabetic rats were given CMHX for 4 weeks.By the end of the experiment,MNCV of the sciatic,SNCV of the caudal nerve and H reflex was detected with evoked elec- tromyogra...