保肝抗纤胶囊防治大鼠肝纤维化的实验研究

Experimental Study on Liver Fibrosis Prevention and Treatment in Rats by Baogan Kangxian Capsule

目的:研究保肝抗纤胶囊治疗肝纤维化的作用。方法:建立 CCl_4高脂低蛋白复合因素所致的大鼠肝纤维化模型,随机分为正常组、模型组、秋水仙碱组、肝脾康组、保肝抗纤高剂量组、保肝抗纤低剂量组,观察用药后血清学及病理变化。结果:保肝抗纤胶囊能提高肝纤维化大鼠生存率,降低血清Ⅲ型前胶原(PCⅢ)及血清透明质酸(HA)值,并能改善肝组织病理学变化。结论:保肝抗纤胶囊有保护肝细胞、减轻肝细胞变性坏死、阻止纤维组织增生、促进纤维组织降解的作用。

Objective:To study the effect of Baogan Kangxian Capsule(BGKXC)in treating liver fibrosis.Methods:Rat model of liver fibrosis was established by combined CCl_4 and high-lipid low-protein forage.The model animals were randomly divided into the model group,the colchicines group,the Ganpikang group and the BGKXC groups of high and low dose.The serologic and pathologic changes were ob- served.Results:BGKXC could raise the survival rate,lower serum levels of pre-collagen type Ⅲ and hyaluronic acid(HA),and improv...