甘草锌抗大鼠实验性胃溃疡的形态学研究

Morphological Study on Effect of Licorzinc in Treating Experimental Gastric Ulcer in Rats

目的:探讨甘草锌治疗胃溃疡的作用机理。方法:采用应激性、幽门结扎型、醋酸型胃溃疡大鼠模型,观察甘草锌抗溃疡作用以及对病灶组织形态学的影响。结果:甘草锌治疗组溃疡体积小于模型组(P<0.01);溃疡病灶组织学检查与模型组比较,溃疡部位坏死及炎症渗出物减少,肉芽组织内的白细胞,尤其是中性粒细胞减少,疤痕层较厚,显微镜下可见成纤维细胞数量增多、功能增强。结论:甘草锌具有促进肉芽组织增长,促进胃上皮细胞的分裂繁殖,有利于溃疡的修复,从而加快损伤的愈合。

Objective:To study the therapeutic mechanism of licorzinc in treating gastric ulcer.Methods:The stressed,pylorus ligated and acetic acid stimulated rat models of gastric ulcer were used to observe the anti-ulcer effect of licorzinc and its effect on histo-morphologic lesion.Results:As compared with the model group,the area of ulcer in the licorzinc treated group was significantly smaller,with less necrosis and inflammatory exudation.Microscopic examination showed in the treated group after treatment,WBC in ...