甲子参芪合剂对大鼠环孢霉素A急性肾毒性的防护作用

Protective Effect of Jiazi Shenqi Mixture on Acute Nephrotoxicity of Cyciosporine A in Rats

目的:探讨中药甲子参芪合剂对大鼠环孢霉素 A(CsA)急性肾毒性的防护作用。方法:观察甲子参芪合剂对急性 CsA 肾毒性大鼠肾功能、尿蛋白、尿β_2-微球蛋白及肾组织病理变化及肾小管间质中细胞间粘附分子-1表达的影响。结果:甲子参芪合剂对大鼠 CsA 急性肾毒性有保护作用,其作用与异搏定及抗细胞间粘附分子-1单克隆抗体治疗效果相似。结论:中药甲子参芪合剂能有效地防护 CsA 对大鼠的肾脏毒性作用。

Objective:To explores the protective effects of J iazi Shenqi Mixture(JZSQM)on acute nephrotoxicity of Cyclosporine A(CsA)in rats.Methods:The effects of JZSQM on renal function,proteinuria,urinary β_2-microglobulin(β_2-MG),renal histology and expression of intercellular adhesive molecule-1(ICAM-1)in the tubulointerstitium in rats with acute nephrotoxicity of CsA were examined.Results: JZSQM has protective effects on rats with CsA nephrotoxicity.The effects are similar to verapamil and anti-ICAM-1 monoclonal...