大鼠脾气虚证模型形成过程中子宫血管舒张—收缩因子的改变

Changes of Vasodilatory and Vasocontrictory Factors of Uterus in the Modeling Process of Spleen Deficiency Syndrome Rat Model

目的:探讨雌性大鼠在泻下一劳倦复合因素作用下,对子宫血管舒张一收缩因子[内皮素(ET)-一氧化氮(NO)]的改变,以及益气止血中药对其影响。方法:采用番泻叶泻下—游泳劳倦复合因素建立脾气虚动物模型,并运用益气止血中药予以治疗干预。结果:雌性大鼠在脾气虚状态下,子宫 ET、NO 及卵巢、子宫重量均有明显有意义变化,益气止血复方拆方及复方都对各指标均有一定调节作用。结论:脾气虚状态下,会引起雌性大鼠的生殖系统的变化,并且出、凝血系统的某些环节受到影响,而再附加特定出血因素时会引起出血倾向,从而从一定程度上证实脾气虚是脾不统血证发生的基础。

Objective:To explore the changes of uterus vasodilatory and vasocontrictory factors[endothelin(ET)and nitric oxide(NO)]un- der the action of complex factors with purgation and fatigue,and the effect of Chinese herbal medicine for supplementing Qi and arrest- ing hemorrhage(SQAH)on them.Methods:The Spleen-Deficiency Syndrome(SDS)model was established by applying the complex factors with Cassia angustifolia induced purgation and fatigue by swimming,and the process of modeling was intervened by SQAH treatment,...