毒素清对大肠杆菌肺炎老龄大鼠细胞因子的影响

Effect of Dusuqing on Cytokine in Aged Rats with Escherichia Coli Pneumonia

目的:研究肺炎老龄大鼠的病理生理特点及中药毒素清对其作用。方法:复制大肠杆菌肺炎模型,分为模型组,毒素清高、低剂量组及氟哌酸组,同时设老龄对照组,共给药6天。观察肺脏组织病理改变,肺泡灌洗液中性粒细胞计数和外周血白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子(TNF)含量。结果:老龄模型组大鼠肺组织损伤明显,肺泡灌洗液白细胞和中性粒细胞计数高于老龄对照组,IL-8、IL-6、TNF 含量增高较老龄对照组显著。与老龄模型组比较,毒素清高剂量组白细胞和中性粒细胞计数降低,用药各组 IL-8、IL-6及 TNF 含量降低,其中高剂量组 IL-8及 TNF 含量低于低剂量组和氟哌酸组。结论:细胞因子紊乱参与老龄大鼠肺炎的病理生理过程,毒素清对其有明显的调节作用,这可能是该方治疗老年人肺炎的机制之一。

Objective:To study the physio-pathologic characteristics of aged rats with escherichia coil pneumonia and the effect of Dusuqing (DSQ)on the disease.Methods:The model rats of pneumonia were divided into the model group,the DSQ groups of high and low dose and the norfloxacin group.The treatment was given for 6 days.t3esides,a control group consisting of aged rats was set up.The changes of pathology of lung,neutrophil count in bronchoalveolar lavage fluid(BALF),and content of interleukin 8(IL-8),interleukin 6...