珍葛降压方对自发性高血压大鼠一氧化氮及内皮素的影响

Effect of Zhenge Hypotension Recipe on Nitric Oxide and Endothelin in Spontaneous Hypertension Rats

目的:探讨珍葛降压方的降压机理。方法:取 SHR 大鼠30只,随机分为生理盐水组、硝苯吡啶组、珍葛降压方高、低剂量组,每天灌胃1次,连续14天。末次给药后摘眼球取血,分别测定血清 NO 和血浆内皮素含量。结果:给药14天后,珍葛降压方高剂量组的 NO 含量为(133.7±9.9)μmol/L,与生理盐水组(118.7±10.9)μmol/L 比较,差异有显著性(P<0.01)。珍葛降压方低剂量组的 NO 含量为(121.6±9.7)μmol/L,与生理盐水组比较,差异无显著性(P>0.05)。珍葛降压方高剂量组的内皮素含量为(254.94±98.22)ng/L,生理盐水组的内皮素含量为(468.10±63.49)ng/L,两组比较差异有显著性(P<0.01)。珍葛降压方低剂量组的内皮素含量为(357.06±104.69)ng/L,与生理盐水组比较差异亦有显著性(P<0.05)。结论:珍葛降压方可升高 SHR 大鼠血清 NO 含量,降低其血浆内皮素的浓度,且可相应升高 NO/ET 的比值,从而降低血压。

Objective:To explore the mechanism of hypotensive effect of Zhenge Hypotension Recipe(ZGH).Methods:Thirty spontaneous hy- pertension rats(SHR)were divided into the control group,the nifedipine group,the high and low dose of ZGH groups.The drugs were administered once a day by gastrogavage for 14 days successively.Blood of animals was collected from eye-hall to determine the serum content of nitric oxide(NO)and plasma content of endothelin(ET).Results:The serum content of NO in high dose ZGH group was 133.7±...