畅脉舒对家兔动脉粥样硬化防治作用的实验研究

Experimental Study on Effect of Changmaishu in Prevention and Treatment of Atherosclerosis in Rabbits

目的:研究畅脉舒对实验性动脉粥样硬化(AS)家兔的防治作用机理。方法:采用高胆固醇饲料喂养,建立家兔 AS 模型,以地奥心血康组为对照,随机分为对照组、模型组、地奥心血康组和畅脉舒用药组,各组在实验第14周取血标本测定血脂、血清一氧化氮(NO)、血浆内皮素(ET)、脂质过氧化物(LPO)和超氧化物歧化酶(SOD)等指标。结果:与模型组比较,畅脉舒用药13周后能提高血清 NO、高密度脂蛋白胆固醇(HDL-C)和 SOD 活性(P<0.05或P<0.01),降低 ET、LPO、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)含量和减轻动脉粥样斑块形成(P<0.05或P<0.01);且在降低 ET、LPO、TG、TC、LDL-C 和减轻动脉粥样斑块形成,升高 NO 含量、SOD 活性和 HDL-C 方面均优于地奥心血康(P<0.05或 P<0.01)。结论:畅脉舒具有降低血脂、抗氧化、减少动脉粥样硬化斑块形成的作用。

Objective.To study the mechanism of Changmaishu(CMS)in preventing and treating experimental atherosclerosis(AS)in rab- bits.Methods:AS model rabbits fromed by high cholesterol forage feeding were randomly divided into the model group,the Di ao Xinxuekang(DX)group and the CMS group.A group of normal rabbits was set up for control.Blood sample was collected at the 14 th week for determining the levels of nitric oxide(NO),endothelin(ET),lipid peroxide(LPO)and superoxide dismutase(SOD),etc.Re- suits:The abnorma...