侧脑室注射川芎嗪对大鼠心脏血流动力学的作用及其机制

Effect of Intra-Lateral Cerebral Ventricular Injection of Tetramethylpyrazine on Cardiac Haemodynamics and Its Mechanism in Rats

目的:探讨川芎嗪对大鼠心脏血流动力学作用及机制。方法:以左心室收缩压(LVSP)、左心室终末舒张压(LVEDP)、左心室最大变化速度(±dp/dt max)为指标,在氨基甲酸乙酯麻醉的 SD 大鼠上观察川芎嗪对上述指标的影响。结果:侧脑室注射川芎嗪后大鼠LVSP、LVDEP、±dp/dt max 明显增加,与生理盐水组和给药前比较差异均有显著性(P<0.01)。侧脑预先注射β受体阻断剂心得安可部分阻断川芎嗪增强 LVSP、LVEDP、±dp/dt max 的作用。结论:川芎嗪有明显增强 LVSP、LVEDP、±dp/dt max 的作用。川芎嗪增强心血管系统的作用可能部分由脑内β受体介导。

Objective:To study the effect and mechanism of tetramethylpyrazine(TMP)on cardiac hemodynamics in rats.Methods:SD rats anesthesized with urethane was used to observe the effect of TMP on LVSP,LVEDP,and±dp/dt max.Results:After intra-lateral cerebral ventricular injection was given to the animal,the LVSP,LVEDP and±dp/dt levels in rats increased,as compared with those before treatment or with those in the control group,the difference was significant(P<0.01).This effect may be partially blocked by pretreatme...