双边栝楼种子中不皂化类脂的化学成分研究

Study on the chemical constituents of unsaponifiable lipids from the seeds of Trichosanthes rosthornii

目的 :研究双边栝楼种子中不皂化类脂的化学成分 ,为制定中药瓜蒌和瓜蒌子的质量标准奠定基础。方法 :乙醚提取脂肪油 ,氢氧化钾进行皂化反应 ,对不皂化类脂进行硅胶柱层色谱分离和纯化 ,用IR ,MS ,1 H NMR ,1 3C NMR等光谱技术和对照品对照等方法鉴定化合物的结构。结果 :鉴定了 6个化合物 ,分别为栝楼仁二醇 (Ⅰ ) ,7 氧化二氢栝楼仁二醇 (Ⅱ ) ,10α 葫芦二烯醇 (Ⅲ ) ,豆甾 7 烯 3β 醇 (Ⅳ ) ,豆甾 7,2 2 二烯 3β 醇 (Ⅴ )和豆甾 7,2 2 二烯 3 O β D 葡萄糖苷 (Ⅵ )。 结论 :前

Objective:To study the chemical constituents of unsaponifiable lipids from the seeds of Trichosanthes rosthornii Harms in order to develop some quality standards for Fructus Trichosanthis and Semen Trichosanthis.Methods:To extract the fatty oil from the seeds of Trichosanthes rosthornii with ether,to carry out the saponification with potassium hydroxide,to isolate and purify the unsaponifiable lipids by using silica gel column chromatography,and to elucidate the structures of their constituents by means of ...