摘要
Aim To study the exchange reaction characteristics of anion exchange resin for diclofenac sodium. Methods The drug-resin complexes were prepared by a batch method with diclofenac sodium as the model drug and the strong anion exchange resin (201 × 7) as the carrier. The effects of different forms (OH~ - and Cl~ - ) of the strong anion exchange resin, the particle size of the resin, and the reaction temperature on the exchange behavior were described. The exchange kinetic profiles were fitted. The related exc...
目的研究阴离子交换树脂与双氯芬酸钠的交换反应特性。方法以双氯芬酸钠为模型药物,以强碱性阴离子交换树脂(201 ×7)为载体,采用静态法制备药物树脂,考察了阴离子交换树脂不同类型(OH-和Cl-)、树脂粒径以及反应温度对交换过程的影响,并对交换动力学曲线进行了拟合,考察了离子交换反应速率常数、活化能和选择性系数,同时考察了交换反应热力学参数吉布斯自由能变化,反应焓变化和反应熵变化。结果Cl-型OH-型阴离子交换树脂对双氯芬酸钠的载药能力相同。树脂粒径越小,反应温度越高,则反应速率越快。药物树脂间的交换反应符合一级动力学反应,反应活化能约为60·68 kJ·mol-1。在303K、313K和323K三种温度下得到的热力学参数都满足于ΔrGθm<0,ΔrHmθ>0 andΔrSmθ>0。结论药物与树脂的交换过程主要受树脂粒径和反应温度的影响,而且该离子交换反应是吸热反应,即升高温度有助于反应正向自发进行。
