期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

卡维地洛固体自微乳化药物传递系统的应用(英文) 被引量：1

Use of Solid SMEDDS in Delivery of Carvedilol
下载PDF
导出
摘要 目的为了提高卡维地洛的溶解度和溶出速度,制备了一种新型的固体自微乳化硬胶囊。方法考察了卡维地洛在各种基质中的溶解度,绘制三元相图用来确定Gelucire 44/14-Lutrol F68-Transcutol P及Tefose 63-Lutrol F68-Transcutol P两种三元系统的有效自乳化和自微乳化区域。优选Gelucire 44/14-Lutrol F68-Transcutol P系统制备了自微乳化硬胶囊,对其粒径分布,ζ-电位及体外溶出特征进行了评价。结果自制自微乳化硬胶囊能够显著地提高药物的体外溶出速率。结论自制卡维地洛固体自微乳化硬胶囊有希望提高药物的生物利用度。 Aim A new solid SMEDDS (self-microemulsifying drug delivery system) capsule has been developed to increase the solubility and dissolution rate. Methods The solubilities of carvedilol in various bases were investigated. Ternary phase diagrams were used to evaluate the self-emulsification and self-microemulsfication domains. The particle size distribution and ζ-potential were determined. The mean diameter of the three formulae decreased with an increase of Lutrol F68. Results The in vitro dissolution rate of ...
作者 魏兰兰 孙佩男 田蕾 唐歆 姚婷婷 潘卫三
机构地区 沈阳药科大学药学院 复旦大学附属华山医院
出处 《Journal of Chinese Pharmaceutical Sciences》 CAS 2006年第4期223-227,共5页 中国药学（英文版）
关键词 自微乳化 卡维地洛 粒径分布 ζ-电位 溶出 self-microemulsification carvedilol particle size distribution ζ-potential dissolution
分类号 TQ460.1 [化学工程—制药化工]
  • 相关文献

参考文献1

  • 1Panayiotis P. Constantinides. Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects[J] 1995,Pharmaceutical Research(11):1561～1572

同被引文献31

  • 1CANNON J B. Oral solid dosage forms of lipid-based drug deliv- ery systems[J]. Am Pharrn Rev, 2005, 8(1) : 108-117.
  • 2NAZZAL S, KHAN M A. Controlled release of a self-emulsifying formulation from a tablet dosage form: stability assessment and optimization of some processing parameters [ J ]. lnt J Pharm, 2006, 315(1-2) : 110-121.
  • 3SARRATONI M, NEWTON M, BOOTH S, et al. Controlled drug release from pellets containing water-insoluble drugs dis- solved in a self-emulsifying system[ J]. Eur J Pharm Biopharra, 2007, 65(1) :94-98.
  • 4POLLARD S, NASHAN B, JOHNSTON A, et al. A pharmacoki-netic and clinical review of the potential clinical impact of using different formulations of cyclosporin A[ J]. Clin Ther, 2003, 25 (6) : 1654-1669.
  • 5JANNIN V, MUSAKHANIAN J, MARCHAUD D. Approaches for the development of solid and semi-solid lipid-based formula- tions[ J]. Adv Drug Deliv Rev, 2008, 60(6) :734-746.
  • 6COLE E T, CADE D, BENAMEUR H. Challenges and opportu- nities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration [ J ]. Adv Drug Deliv Rev, 2008, 60(6) :747-756.
  • 7BALAKRISHNAN P, LEE B T, OH D H, et al. Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system ( SEDDS ) [ J ]. Eur J Pharm Biopharm, 2009, 72(3) : 539-545.
  • 8CORVELEYN S, REMON J P. Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs[ J]. Int J Pharm, 1998, 166(1) : 65-74.
  • 9YI T, WAN J L, XU H B, et al. A new solid self-microemulsify- ing formulation prepared by spray-drying to improve the oral bio- availability of poorly water-soluble drugs[ J]. Eur J Pharm Biop- harm, 2008, 70(2) : 439 -444.
  • 10REMEDIA S R L. Pharmaceutical composition comprising an oil/ water/oil double microemulsion incorporated into a solid support: WIPO, W003/051334 A2[ P]. 2003-06-26.

引证文献1

二级引证文献5

Journal of Chinese Pharmaceutical Sciences
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部