OFA/C三联抗幽门螺杆菌治疗的临床观察

The Clinical Observation on Hp Therapy by OFA/C Trigeminy Treatment

目的:探讨一种安全有效价廉的根治幽门螺杆菌(Hp)的治疗方案。方法:2005年4月至2007年4月符合标准病例64例,随机分为治疗组33例[男性19例,女性14例,平均年龄(45.2±6.5)岁],对照组31例[男性25例,女性6例,平均年龄(41.3±8.5)岁]。采用OFA/C方案:奥美拉唑(Omeprazole)、呋喃唑酮(Furazolidone)和阿莫西林克拉维酸钾(Amoxicillin/ClavulanicAcid)三联治疗,与用奥美拉唑、阿莫西林(Amoxicillin)及甲硝唑(Metron-idazole)方案进行比较。结果:治疗组显效达28/33(84.85%),有效达2/33(6.06%);对照组显效达19/31(61.29%),有效达6/31(19.35%),二者间统计学差异有显著性(P<0.05)。人均医疗费用治疗组(180±40)元;对照组(1494±201)元,差异有统计学意义(P<0.01)。治疗组出现2/33(6%)例轻度不良反应,对照组出现5/31(16%)例轻度不良反应,差异无统计学意义(P>0.05)。结论:用OFA/C方案治疗幽门螺杆菌具有疗效显著、不良反应轻微、费用少的优点。

Objective To explore one safe,effective and inexpensive therapeutic plan on Hp treatment.Methods 64 patients with Hp were separated observation group 33 cases[male 19,female 14,mean years old(45.2±6.5)]and control group 31 cases[male 25,female 6,mean years old(41.3±8.5)]randomly from April 2005 to April 2007.OFA/C schedule(Furazolidone,Amoxicillin /Clavulanic Acid) to study group and OAM schedule(Omeprazole,Amoxicillin and Metronidazole) to control group and their results were compared with each other.Resul...