原发性肝癌术后复发与性激素失衡的关系研究

Relationship between sex hormone and recidivation after operation in primary hepatocellular carcinoma

目的探讨原发性肝癌术后复发与性激素水平的关系。方法将试验对象共分为3组,分别为正常对照(A,n=10例)组,肝硬化(B,n=10例)组及肝癌(C,n=40例)组;实验用放射免疫固相法检测3组患者术前血中雌二醇(E2)及睾酮(T)的含量,并对肝癌组患者术后1、4、16、32周时E2及T含量进行检测;用EnVision法检测各组肝脏组织中AR和ER的阳性率,对3组间数据进行比较分析;结果术前血浆E2、T水平在肝硬化、肝癌及对照组中差异无显著性,但E2/T在肝癌组中较其他两组有显著增高;肝癌组术后E2/T水平有下降趋势,至术后16周时再次升高,而肝癌复发患者E2/T值在术后16、32周时再次显著升高,且在肝癌复发者AR(+)比例与肝癌组AR(+)相比显著升高(P<0.05);结论肝癌的发病可能与性激素水平比值失衡有关,肝癌复发可能与性激素比例失衡及AR(+)有关。

Objective To investigate the relationship between sex hormone and recidivation after operation in primary heaptocellular carcinoma.MethodSixty male were divided into three groups, Control group(A, n=10), hepatic cirrhosis group(B, n =10) and Primary Hepatocellular Carcinoma group(C, n =40).Estradiol(E2), testosterone(T), Sex-hormonic receptor(ER and AR) were detected in all groups before operation, and were detected in 1 week, 4 week, 4 month, 8 month after operation in C group.ResultsThe level of E2 and T ...