烧伤创面合并单纯疱疹病毒Ⅰ型感染的临床观察

Clinical investigation of burn wound infection with type I herpes simplex virus

目的 通过对 6 2例患者浅度烧伤创面的观察 ,分析单纯疱疹病毒 (HSV -Ⅰ )的感染特点 ,并提出治疗方案。 方法 采用细菌培养、PCR病毒检测和免疫组化染色、病理切片等方法对 7例患者进行检测 ,排除其他原因并确诊。同时对 6 2个病例的临床表现、发病过程及病理特点进行记录和总结。 结果 烧伤创面被瘤状物覆盖 ,外观呈菜花状。被检测的 7例患者中 ,有 5例HSV -Ⅰ阳性。显微镜下表皮细胞呈气球状及网状变性 ,气球状细胞内可见包涵体。后期表皮棘细胞层明显增生呈假乳头状瘤样 ,基底细胞液化明显。患者以局部症状为主 ,全身反应较轻 ,外用新霉素加无环鸟苷湿敷效果较好。 结论 烧伤创面被HSV -Ⅰ感染后临床症状典型 ,结合PCR病毒检测及免疫组化染色可明确诊断。非手术保守治疗可以治愈。

Objective To elucidate the clinical features of burn wound infection with type I herpes simplex virus (HSV-1), so as to propose the possible therapeutic measures. Methods Burn wound infection with HSV-1 was diagnosed in 7 cases by means of bacterial culture, PCR detection of virus, immunohistochemical staining and pathomorphological section with the exclusion of other causes. In addition, the clinical signs and the features of the development of the infection in 62 cases were recorded and analyzed. ...