丁型肝炎病毒阳性重型乙型肝炎患者死亡的临床研究

Clinical study on hepatitis D virus-positive patients died from severe hepatitis B

目的探讨了型肝炎病毒（ＨＤＶ）在重型乙型肝炎发展中的作用。方法以同期单纯ＨＢＶ（＋）重型肝炎死亡者２４４例为对照组，７６例ＨＤＶ（+）重型乙型肝炎死亡者进行临床表现、体征、并发症及主要生物化学指标比较。结果ＨＤＶ（＋）死亡组腹水（５１．３％）、腹胀（８８．２％）、消化道出血（４８．７％）与对照组（分别为３６．８％，７７．１％，３３．８％）差异有显著意义（ｘ２值分别为 ５．９６、 ４．４１和 ５．９７， Ｐ＜ ０．０５）；肝肾综合征（４６．１％）、细菌感染（５３．９％）及两种或两种以上并发症发生率（７６．３％）与对照组（２８．５％、３５．７％和５３．８％）差异有显著意义（ｘ２值分别为７．９３、８．０８和１２．２７，Ｐ＜ ０．０１）；生物化学指标总胆红素［（４８５．４５± １０７．６０）μｍｏｌ／Ｌ］、谷丙转氨酶［（３８．７６±２０．１５）Ｕ／Ｌ］、凝血酶原活动度（１９．０８％ ± ８．０９％）与对照组［（４０７．７５±９８．５４）μｍｏｌ／Ｌ、（５６．８６ ± ２６．７５） μｍｏｌ／Ｌ、（２３．８５ ± １４．０７） μｍｏｌ／Ｌ］比较差异有显著意义（ ｕ值分别为 ５．６１、 ７．３３和 ３．６７，Ｐ＜ ０．０１）。结论 ＨＤＶ?

Objective To investigate the role of hepatitis D virus (HDV) in the development of severe hepatitis B. Methods Seventy-six HDV-positive patients died from severe hepatitis B were compared with 244 HDV-negative patients from severe hepatitis B in clinical manifestations, signs, complications and main biochemical indexes at the same period. Results HDV-positive patients had obvious ascites, abdorninal distension, digestive tract hemorrhage as compared with the HDV-negative ones (P<0.05). There were significan...