尿路致病性大肠埃希菌和宿主膀胱防御反应的相互作用

Bad Bugs and Beleaguered Bladders:Interplay between Uropathogenic Escherichia Coli and innate Host Defenses

尿路致病性大肠埃希菌(uropathogenic Escherichia coli,UPEC)是大部分尿路感染的病原菌.大多数UPEC表面具有纤毛状的粘附器官1型菌毛.1型菌毛介导细菌与膀胱上皮细胞接触,且侵入其中.UPEC侵入细胞后获得一个保护性环境,或在其中繁殖,或处于静止潜伏状态.具1型菌毛的UPEC侵入细胞引发了宿主的一系列反应:细胞激酶的产生,炎症反应和受感染膀胱上皮细胞的片状脱落.宿主反应和抗生素治疗虽能有效清除尿中细菌,但致病菌可顽固地存在于膀胱组织中,从而成为复发性尿路感染的难治根源.

Strains of uropathogenic Escherichia coli(UPEC)are the causative agents in the vast majority of all urinary tract infections. To gain an initial foothold within the bladder, most UPEC strains encode filamentous surface adhesive organelles called type 1 pili that can mediate bacterial cells. Invasion provides UPEC with a protective environment in which bacteria can either replicate or persist in a quiescent state. Infection by E. coli with type 1-pil: can trigger a number of host responses, including cytokin...