甲亢、甲减患者血浆心钠素水平的改变

Serum Atrial Natriuretic Factor Level in Hyrerthyroidism and Hypothyroidism

目的 探讨甲状腺功能亢进症 (甲亢 )、甲状腺功能减退症 (甲减 )病人血浆心钠素 (ANF)水平的改变。 方法 甲亢、甲减病人为观察组 ,献血者为对照组。采用双抗体 -聚乙二醇放免法测定血浆 ANF水平。 结果 (1)甲亢病人治疗前 ANF水平明显高于对照组 (P<0 .0 1) ,甲减病人治疗前则低于对照组 (P<0 .0 1)。 (2 )甲亢、甲减治疗前后 ANF水平差异有显著性 (P<0 .0 5 ) ,经治疗后 ANF恢复正常。 (3)甲亢心脏病人 ANF水平明显高于无甲亢心脏病 (P<0 .0 1)。相关分析显示 ANF与 FT3呈正相关 (P<0 .0 1)。 结论 ANF可作为判断甲状腺疾病病情轻重以及考核疗效的指标。

Objective\ To study the serum atrial natriuretic factor(ANF) level in hyperthyroidism and hypothyroidism.\ Methods\ The serum ANF were measured in hyperthyroidism and hypothyroidism by radio\|immunol assay(RIA).\ Results\ The serum ANF level was higher in hyperthyroidism and lower in hypothyroidism than controls before treatment(P<0 01).\ But the serum ANF level all returned to normal after treatment(P<0 05).\ Patients with heart disease in hyperthyroidism had higher level of ANF compared with hyperthyroi...