冠状动脉介入术中地尔硫的即刻降压效果

Effect of diltiazem on decline of blood pressure in patients undergoing percutaneous coronary intervention

目的 :观察地尔硫在冠状动脉介入术中的即刻降压效果。方法 :5 1例术中高血压病人经动脉或静脉注射地尔硫 (0 .2～ 0 .3mg·kg- 1) ,3min推注完毕 ,记录即刻 ,5 ,10 ,2 0 ,30min血压和心率变化。结果 :地尔硫能使收缩压从注射前的 (2 5 .1± 2 .5 )kPa降至注射后即刻的 (2 0 .1± 2 .4 )kPa(P<0 .0 1)。 10min后逐渐回升 ,30min时为 (2 3.2±2 .5 )kPa ,仍明显低于用药前 (P <0 .0 1) ;舒张压由注射前的 (12 .7± 1.5 )kPa降至即刻的 (10 .4±1.3)kPa(P <0 .0 1) ,10min后逐渐回升 ,30min时为 (11.5± 1.3)kPa ,仍低于用药前 (P <0 .0 1)。结论 :经动脉或静脉注射地尔硫能迅速有效地控制冠状动脉介入术中的高血压 ,有利于手术的顺利进行。

AIM: To observe the antihypertensive effect of diltiazem in patients undergoing percutaneous coronary intervention. METHODS: Fifty one patients with hypertension during the operation were adminstrated intra arterial or intravenous injection of diltiazem (0.2～0.3 mg·kg -1 ,3 min). The blood pressure and heart rate before or immediately, 5,10, 20 and 30 min after injection were recorded respectively. RESULTS: Immediately after the administration of diltiazem, the systolic blood pressure was signific...