期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

增殖细胞核抗原与肺鳞状细胞癌临床病理特征的相关性 被引量：2

RELATION BETWEEN THE EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN AND PROGNOSIS IN LUNG SQUAMOUS CELL CARCINOMA
原文传递
导出
摘要 目的 :探讨增殖细胞核抗原 (PCNA)在肺鳞状细胞癌 (简称 )组织中的表达及其与预后的关系。方法 :5 1例手术切除的肺鳞癌组织 ,采用免疫组化 (SP)法检测 PCNA在不同临床分期及分化程度癌组织中的表达 ,应用 t检验、方差分析 (F检验 )比较其差异 ;采用 Spearm an等级相关分析其相关性。生存率分析采用 Kaplan- Meir曲线 ,L ong- Rank test检验生存期的差异。结果 :PCNA表达在不同的临床分期及分化程度间差异均显著 (P<0 .0 5 )。 PCNA和临床分期及分化程度与生存期均呈正相关 ,PCNA指数 >5 0 %组生存期明显短于 PCNA指数 <5 0%组 (P<0 .0 1)。结论 :PCNA在一定程度上可以作为肺鳞癌评价预后的指标。 Objective:To investigate the relation between the expression of proliferating cell nuclear antigen (PCNA) and prognosis in lung squamous cell.Methods:The expression of PCNA on 51 cases carcinoma tissues were detected by immunohistochemical SP technique. Thet test and F test was used to analyze the difference of expression of PCNA in different pathological grades and clinic stages.Spearman Grade-relation test was used to analyze the relation between PCNA expression and pathological grades.The difference of s...
作者 司品现 杨渝浩 董德琼 孙显明
机构地区 山东省济宁市第一人民医院 遵义医学院附属医院
出处 《肿瘤研究与临床》 CAS 2001年第3期161-162,共2页 Cancer Research and Clinic
关键词 肺肿瘤 鳞状细胞癌 增殖细胞核抗原 预后 Lung carcinoma Squamous cell Carcinoma PCNA Prognosis
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献5

  • 1Frierson H F.Pioidy analysis and S-Phase fraction detemination by flow cytometry of invasive adenocarcinoma of the breast[].The American Journal of Surgical Pathology.1991
  • 2Rodrigo B,Rainer F,Patricia A,et al.Cyclin PCNA is the auxiliary protein of DNA polymerase-[].Nature.1987
  • 3Dierendone R J,Wijsman J H,Keijzer R,et al.Cell cycllerelated staining patterns of anti -preliferating cell nuclear antigen monoclonal antibodies[].American Journal of Pathology.1991
  • 4Hall P A,Levison P A,Woods A L,et al.Proliferative cell nuclear antigen ( PCNA) immunolocalization in paraffin section:An index of cell proliferation with evidece of deregulated expression in some neoplasms[].Journal of Paleopathology.1990
  • 5Pierre R,Thomas L,Barbara H,et al.Prognosis significance of the proliferating cell nuclear antigen activity in neuroblastoma[].American Journal of Pathology.1997

同被引文献19

  • 1张世馥.细胞周期--材料和方法[M].北京:人民卫生出版社,2000;12:237～239
  • 2Frontani G, Pingitore R,Bigini E, et al. Growth fraction in non-smali cell lung cancer estimated by proliferating cell nuclear antigen and comparison with ki67 labelling and DNA flow cytometry data [J]. Am J Pathol, 1992; 141(6):1285
  • 3Silvestrini R, Costa A, lequaglie C, et al. Bcl-2 protein and progonsis in patients with potentially curable non-small-cell lung cancer[J]. Virchows, 1998;732(5):441
  • 4Rose C, Anton, Md, dt al. Absence of prognostic significance of Bcl-2 immunopositivity in non-small lung cancer:analysis of 427 cases[J]. Hum Pathol, 1997;28(9):1079
  • 5Fontaini G, Viganati S, Bigini D, et al. Bcl-2 protein: a prognostic factor inversely correlated to P53 in non-small-cell lung cancer[J]. Br J Cancer, 1995;71(5):1003
  • 6Laudanski J, Chyczewski l, Niklinska WE, et al. Expression of Bcl-2 protein in non-small cell lung cancer: correlation with clinicopathology and patient survival [J]. Neoplasma, 1999;46(1):25
  • 7Silvestrini R, Costa A, Lequaglie C, et al. Bcl-2 protein and prognosis in patients with potentially curable non-small-cell lung cancer [J]. Virchows Arch, 1998;432(5):441
  • 8Rose C, Anton, Md, et al. Absence of prognostic significance of Bcl-2 immunopositivity in non-samll lung cancer: analysis of 427cases [J]. Hum Pathol, 1997;28(9):1079
  • 9David M*Hockenbery, Zolton N*oltval, Xiao Ming Yin, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis [J]. Cell, 1993;75:241
  • 10James J. Ryan, Prochownik E, Gottlieb et al. C-myc and Bcl-2 modulate P53 function by altering P53 subcelluar trafficking during the cell cycle [J]. Proc Natl Acad Sci USA, 1994;91:5878

引证文献2

二级引证文献1

肿瘤研究与临床
2001年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部