Graves’病甲亢患者血清脂质成分的变化

CHANG OF SERUM LIPID COMPONENTS IN PATIENTS WITH GRAVES' HYPERTHYROIDISM

目的观察Ｇｒａｖｅｓ’病甲亢患者血清ＴＣ、Ｔｇ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００和Ｌｐ（ａ）变化并探讨其可能机制。方法采用配对方法比较Ｃａａｖｅｓ’病甲克患者组（甲亢组）和正常对照（正常组）血清ＴＣ、Ｔｇ、ＬＤＬ－Ｃ、ＨＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００和Ｌｐ（ａ）差异。结果甲亢组较正常组血清ＴＣ明显降低，有高度显著性差异，ｐ＜ ０．０１；甲亢组较正常血清 Ｔｇ、ＬＤＬ－ Ｃ、ＨＤＬ－ Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００降低，均有高度显著性差异，ｐ＜０．０１；甲亢组较正常血清Ｌｐ（ａ）降低，但无显著性差异，ｐ＜０．０１。结论（１）Ｇｒａｗｅｓ’病甲亢病人血清ＴＣ、Ｔｇ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、ＡｐｏＡ、ＡｐｏＢ１００均降低，以ＴＣ更明显；（２）尽管甲亢病人血清ＨＤＬ－Ｃ、ＡｐｏＡ１水平降低，但与动脉粥样硬化相关的ＴＣ、Ｔｇ、ＬＤＬ－Ｃ、ＡｐｏＡＩ、ＡｐｏＢ１００也同步降低。因此，我们是否可以推测对于肥胖伴高脂血症，尤其是Ｔ４偏低的病人是否可使用Ｔ４减肥同时降低高脂血症；（３）甲亢病人血清Ｌｐ（ａ）虽有轻度降低，但进一研究甲亢病人的Ｌｐ（ａ）变化及其机理是必要的。

Objective To investigate the change and possible mechanisms of serum TC,LDL-C,HDL-C,ApoAI,ApoB100,and Lp (a) in patients with Graves' hyperthyroidism.Method serum TC,Tg,LDL-C, HDL - C, ApoAI, ApoB100 and Lp(a) in both groups of the Patients with Graves' hyperthyroidism and normalcontrol was compared by paired study.Result In both groups of patients with Craves' hyperthy- roidism and normal control, serum TC decreased significant differently(P< 0.01) .Tg, LDL - C, HDL-C, HDL - C, ApoAl, ApoB100 decreased significantly (P<0.05):Lp(a) decreased,but not different significantly(P>0.05) .Conclusion These findings suggest that the serum TC, Tg, HDL - C, LDL - C, ApoAI, ApoB100 decreased in patients with Graves' hyperthyroidism. the serum TC,Tg, LDL - C, ApoB100 levels with anti - atherosclerosis factors decreased, HDL- C, ApoAI decreased with atherogenic factors at same time.Thus,we guess that obesitic patients with hyperlipidimia and slight low serum T4 are treated effectively;3. serum Lp(a) level of patients with Graves'hyperthyroidism is not significantly different,but it is necessary to investigate the mechanism of serum Lp(a) level of patients with Graves', hyperthyroidism, although some studies seem evident in patients with Graves' hyperthyroidism.