表面灌流β-酪啡肽对离体仔猪胃窦分泌胃泌素的影响

The effect of β-casomorphin on gastrin secretion of piglet'gastric antrum under superfusion

酪蛋白经水解能产生多种生物活性肤，其中具有阿片样活性的β－酪啡肽7（β-CM7）。本文以体外表面灌流，探讨β-CM7，对不同日龄猪胃窦粘膜分泌胃泌素的影响。结果显示，β-CM：能显著促进1、5、10、28日龄仔猪胃窦粘膜分泌胃泌素，并以1日龄的仔猪胃窦粘膜最敏感；28日龄仔猪胃窦粘膜对刺激的反应持续时间最长。提示：乳蛋白不仅被动地作为幼畜的营养物，并具有潜在的信息功能，能影响胃肠道的内分泌；不同日龄的仔猪对其反应不同，反映了营养物与动物的互作。

Several bioactive peptides are derived from casein by incomplete hydrolysis, including β-casomorphin7(β-CM7), an opioid-like peptide. Super fusion has been employed in this experimem to investigate the effect of β-CM7 can significantly stimulates 1,5, 10,28 days' piglets to secrete gastrin. The reaction of the gastric antrum of 1 day's piglets is the most sen- sitive, while the gastrie antrum of 28 day's piglets shows the longest reactive time. The resuh indieates that milk proteins are not only as passive nutrition of neonate animals , but also possess ahent signaling function to affect the gastrointestinal endocrine system. The different reactions of piglet of different days reflect the interaction between nutrition and animals.