血脂康对高脂血症患者血管内皮功能的影响

Effect of Xuezhikang on Endothelial Function in Patients with Hyperlipoidemia

为探讨血脂康对高脂血症患者血管内皮功能的改善作用 ,5 8例高脂血症患者随机分为两组 ,分别给予血脂康或安慰剂治疗 8周 ,利用高分辨率超声测定血流介导的肱动脉舒张及其对硝酸甘油的反应 ,并观察血脂变化。结果显示 ,两组治疗前血脂水平相似 ,血脂康治疗后血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯分别下降2 1 5 %、2 8 2 %和 16 2 % ,血流介导的血管舒张显著增加 (P <0 0 1) ,而安慰剂治疗组无显著差异。两组硝酸甘油介导的舒张相似 ,治疗前后均无显著差异。以上表明 ,血脂康可降低高脂血症患者血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平 。

Aim To study the improved effect of Xuezhikang on endothelial function in patients with hyperlipoidemia. Methods Patients with hyperlipoidemia were randomized to placebo(n=28)or Xuezhikang 0.06 g daily(n=30) for 8 weeks.Brachial ultrasound was used to measure endothelium dependent flow mediated dilatation (FMD)and response to endothelium independent nitroglycerin. Serum lipid profile was determined enzymatically. Results Total and LDL cholesterol and TG levels were similar before randomization in both groups. With Xuezhikang,not with placebo, they decreased by 21.5%(P<0 01)and 28.2%(P<0 01)and 16.2%(P<0 01) respectively. FMD was unchanged with placebo,2.98±2.16 to 3.23±1.89,but increased with Xuezhikang, 2.86±1.59 to 6.47±2.72 (P<0 01). Responses to nitroglycerin were similar in the two groups. Conclusions Xuezhikang could markedly decrease serum TC and LDLC and TG concentration and improve endothelial function in patients with hyperlipoidemia.