胃、结肠癌患者外周血淋巴细胞化学发光与TNM分期的关系

The relationship between chemi-luminescence in peripheral blood lymphocyte and TNM stage in patients with gastric and colorectal carcinoma

目的 :观察不同 TNM分期胃、结肠癌患者外周静脉血淋巴细胞化学发光 (L y- CL)的变化 ,探讨 L y- CL 的意义。 方法 :选择 70例胃、结肠癌患者 ,根据手术病理 TNM分期分组 ,检测入院时患者外周静脉血的淋巴细胞化学发光 ,分析比较不同 TNM分期患者 L y- CL 强度。 结果 :患者 L y- CL 均显著低于正常人 (P<0 .0 1) ,而且 TNM分期愈晚 ,L y- CL 强度愈弱 ,各期两两之间差异显著 (P<0 .0 1)。而胃癌与结肠癌两个病种之间的化学发光强度无显著差异 (718.6 8± 15 2 .49vs 82 7.13± 10 1.91,P>0 .0 5 )。 结论 :胃、结肠癌患者 L y- CL强度减弱 ,与肿瘤

Objectives:To observe the changes of chemi luminescence in peripheral blood lymphocyte (Ly CL) in gastric and colorectal carcinoma patients of different TNM stages. Methods: Seventy gastric and colorectal carcinoma patients were divided into five groups according to the different TNM stages, Ly CL was detected on admission. Results:The CL was less intense significantly ( P <0.01) in patients than healthy controls. The more advanced the TNM stage, the more reduced the CL, the difference were significant( P <0.01). CL intensity between gastric carcinoma and colorectal carcinoma was not different significantly(718.68±152.49 vs 827.13±101.91, P >0.05). Conclusions: Ly CL was decreased in gastric and colorectal carcinoma patients, the extent was related to the TNM stage.