不同生物相容性透析膜对红细胞免疫功能的影响

Influence of different dialysis membranes on erythrocyte immune function

目的 了解血液透析病人透析过程中红细胞免疫功能指标的动态改变及不同生物相容性的透析膜对其变化的影响。方法 分别采用铜仿膜 (Cu膜 )、聚砜膜 (Ps膜 )、聚甲基丙烯酸甲脂膜 (PMMA膜 ) ,观察了透析过程中不同时相的红细胞免疫功能指标RBC C3 b和RBC IC的变化。结果 尿毒症病人的RBC C3 b显著下降 ,RBC IC显著增高 ;透析开始后 ,早期RBC C3 b进一步下降 ,其后逐渐上升 ;而RBC IC早期逐渐增加 ,其后逐渐稳定 ;Cu膜能明显地影响红细胞的免疫功能 ;Ps膜次之 ;PMMA膜对其影响最小。结论 在血液透析过程中 ,使用不同生物相容性的透析膜对透析病人的红细胞免疫功能会产生不同的影响。

Objective To examine the change of erythrocyte immune adherence parameters during the haemodialysis and the influence of different biocompatible dialysis membranes on it.Methods We have observed the dynamic trend of erythrocyte immune adherence parameters at different hemodialysis phase by way of different biocompatible membrane.Results RBC C\-3b declined and RBC IC increased obviously in uremia patients.During the haemodialysis,RBC C\-3b declined even more in the early phase and then increased gradually;RBC IC increased gradually in early phase,and then kept steady.Cu membrane influenced the erythrocyte immune adherence function greatly,Ps membrane moderately,and PMMA membrane slightly.Conclusion The dynamic trends of erythrocyte immune adherence parameters change with the different biocompatible membrances used during hemodialysis.