期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

核因子-κB与炎症 被引量：1

Nuclear Factor-κB and Inflammation
下载PDF
导出
摘要 NF-κB是近年来研究较多的一类重要的转录因子 ,它参与许多与免疫炎症有关的细胞因子、粘附分子的转录调控 ,在免疫反应、炎症的形成过程中起重要作用 .抑制NF -κB的活性 。 As a kind of important transcription factor,NF-κB is frequently researched in recent years. It can regulate the expression of cytokines and adhesion molecules which are involved in immunity and inflammation,and plays an essential role in the course of immune reaction and inflammation. Inhibited NF-κB activation may be used in inflammatory therapy.
作者 王永堂 蒋建新 李关荣
机构地区 西南农业大学生命科学系 第三军医大学野战外科研究所
出处 《生命科学研究》 CAS CSCD 2001年第z1期97-101,共5页 Life Science Research
基金 国家重点基础研究发展规划资助项目 (G19990 5 42 0 3)
关键词 NF-ΚB 炎症 基因表达 调控 NF-κB inflammation gene expression regulation
分类号 Q7 [生物学—分子生物学]
  • 相关文献

参考文献25

  • 1[1]SEN R,BALTIMORE D.Multiple nuclear factors interact with the immunoglobulin enhancer sequences[J].Cell,1986,46(5):705-716.
  • 2[2]SHAMES B D,SELZMAN C H,MENG X,et al. Genes Dont Count[J].Arch Surg,1998,133(6):667-669.
  • 3[3]ALBERT S,BALDWIN Jr.The NF-κB and IκB proteins:new discoveris and insights[J].Annu Rev Immunol,1996,14(4):649-683.
  • 4[4]BOHRER H,QIU F, ZIMMERMANN,et al. Role of NF-κB in the mortality of sepsis[J]. J Clin Invest,1997,100(5):972-985.
  • 5[5]PIETTE J,PIRET B.Multiple redox regulation in NF-κB transcription factor activation[J].J Biol Chem,1997,378(11):1237-1245.
  • 6[6]TAYLOR B S,DE V M,GANSTER R M,et al. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene[J]. J Biol Chem,1998,273(24):15148-15156.
  • 7[7]WANG C Y,MAGYO M W,BALDWIN A S Jr. TNF-and cancer terapy-indeced apoptosis:potentiation by inhibition of NF-κB[J]. Science,1996,274(5288):784-787.
  • 8[8]LIN Y C,BROWN K,SIEBENLISH U,et al. Activation of NF-κB requires proteolysis of the inhibitor IκB-α:signal-induced phosphorylation of IκB-α alone does not release active NF-κB[J]. Proc Nati Acad Sci USA,1995,92(2):552-556.
  • 9[9]KROLL M,MARGOTTIN F,KOHL A,et al. Inducible degrudation of IκB-α by the proteasome requires interaction with the F-box protein h-βTrCP[J]. J Biol Chem,1999,274(12):7941-7945.
  • 10[10]BARNES P J,ADCOCK I M.NF-κB:Apivotal role in asthma and a new target for therapy[J]. Trends Pharmacol Sci,1997,18(2):46-50.

同被引文献10

  • 1Zhang Y,Proenca R,Maffei M,et al.Positional cloning of the mouse obese gene and its human homologue.Nature,1994,372(6505):425-432.
  • 2Sitaraman S,Liu X,Charrier L,et al.Colonic Leptin:source of a novel pro-inflammatory cytokine involved in inflammatory bowel disease.FASEB J,2004,[in press].
  • 3Udagawa Jun,Hatta Toshihisa,Naora H,et al.Expression of the long form of leptin receptor (Ob2Rb) mRNA in the brain of mouse embryos and newborn mice.Brain Res,2000,868:251-258.
  • 4Grilardi N,Skoda RC.The leptin receptor activates Janus kinase2 and signals for proliferation in a factor-dependent cell line.Mol Endocrinol,1997,11:393-399.
  • 5Harvey J,Ashford M L J.Leptin in the CNS:much more than a satiety signal.Neuropharmacology,2003,44:8541-8545.
  • 6Bjorbaek C,Elmquist J K,Frantz JD,et al.Identification of SOCS-3 as a potential mediator of central leptin resistance.Mol Cell,1998,1 (4):619-625.
  • 7Zhongbiao Wang,Manuel R Castresana,Kristina Detmer,et al.An IκB-α Mutant Inhibits Cytokine Gene Expression and Proliferation in Human Vascular Smooth Muscle Cells.J Surg Res,2002,102:198-206.
  • 8Zhongbiao Wang,Manuel R Castresana,Walter H.Newman.NF-κB is required for TNF-α-directed smooth muscle cell migration.J Surg Res,2001,508(3):360-364.
  • 9Peter Zahradka,Jeffery P Werner,Shelly Buhay,et al.NF-κB Activation is Essential for Angiotensin II-dependent Proliferation and Migration of Vascular Smooth Muscle Cells.J Mol Cell Cardiol,2002,34:1609-1621.
  • 10Brand K,Sharon P,Gerhhard R,et al.J Clin Invest,1996,97:1715-1722.

引证文献1

二级引证文献2

生命科学研究
2001年 第z1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部