亚叶酸钙不同给药途径拮抗氨甲喋呤胃肠道反应的临床研究

Clinical research about the effect of different administration method of calcium Folinate to anti gastrointestinal(GI)reaction induced by methotrexate(MTX),

目的 :探讨亚叶酸钙不同给药途径拮抗氨甲喋呤胃肠道反应的效果。方法 :将接受HDMTX加CF化疗的 6例急性淋巴细胞性白血病患儿随机分为两组 ,观察组口服给药 ,对照组肌注给药 ,对比两组患儿的胃肠道反应。结果 :观察组胃肠道反应明显轻于对照组 (P <0 0 5 )。结论 :亚叶酸钙口服给药比注射给药能明显减轻氨甲喋呤的胃肠道反应。临床应用亚叶酸钙拮抗氨甲喋呤的毒副作用时 。

Objective:Clinical research about the effect of different administration method of calcium Folinate to anti gastrointestinal(GI)reaction induced by metho trexate(MTX) Method:96 cases acute lymphotic leukemia(ALL) children receiving MTX+CF chemotherapy were divided into two groups:oral uptake group and control Result:Experiment group suffer from milder GI reaction than control(P<0 05) Conclusion:Oral uptake of CF can induce milder GI reaction than intramuscular injection group