血栓性脑梗死患者血清同型半胱氨酸水平变化及意义

Serum homocyt(e)ine in patients with thrombolic cerebral infarction

为探讨血栓性脑梗死 (TCI)患者血清同型半胱氨酸 H(e)水平与其他中风危险因素之间的关系 ,用高效液相色谱法 (HPL C)测定脑梗死患者血清 H(e) ,简易智力状态检查法 (MMSE)评定痴呆 ,分析脑梗死患者血清 H (e)水平与相关因素之间的关系。结果显示 ,TCI患者血清 H (e)显著高于脑栓塞 (ECI)组和对照组 ,且与高血压、糖尿病、高血脂、性别、年龄无关 ;脑梗死中痴呆患者血清 H(e)显著高于非痴呆患者。提示血清 H(e)升高为独立于高血压、糖尿病和高血脂之外脑血管疾病的重要危险因素之一 。

To investigate the serum homocyst(e)inelevels of patients with thrombolic cerebral infarction(TCI)and the relationship between H(e)and other risk factors of stroke The serum H(e)levels were assayed by high performance liquid chromatography(HPLC) The dementia was evaluated by mini mental state test(MMSE) The relationship between H(e)and other risk factors were analysized Results showed that the patients with TCI had significantly higher serum H(e) levels than the patients with embolic cerebral infarction and normal groups,and serum H(e)levels were not related to other risk factors The patients with dementia had higher serum H(e)than those without dementia This suggests that the higher serum H(e) is a important independent risk factor for TCI,and involve in the pathogenesis of vascular dementia