非发酵菌的临床检出状况及耐药特点

Determination of Non-zymophtes and Their Drug-res39istance

目的 :为了了解非发酵菌在临床标本中的分布状况及其耐药特点 ,为临床治疗此类细菌感染提供依据。方法 :按常规方法进行菌株分离 ,然后采用VITEK仪进行鉴定及药敏分析。结果 :共检出非发酵菌 318株 ,占总检出菌数的 2 6 .32 % (318/ 12 0 8)主要为铜绿假单胞菌 16 2株占 5 0 .94%、不动杆菌 75株占 2 3 .5 8%、嗜麦芽窄食单胞菌 5 6株占 17.6 1%。铜绿假单胞菌对阿米卡星、头孢他啶、亚胺硫霉素较敏感 ,鲍曼不动杆菌对亚胺硫霉素较敏感 ,嗜麦芽窄食单胞菌对复方新诺明、头孢他啶较敏感。结论 :非发酵菌已成为主要致病菌占临床感染的 1/ 4,种类分布广 ,耐药性严重 ,临床治疗的根本方法是早期、足量。

Objective: To investigate the distribution of non-zymophtes in clinical specimens and its drug-resistance to help with the prevention and cure of infection resulted from them. Methods: The isolates were separated by a routine separation method and their identification and susceptiblity tests were proceeded by bacteria analyzer. Results: The detection rate of non-zymophyte was 26.32% (318/1208). Pseudomonas aeruginosa, X. meltophilia and Acinetobacten baumanii accounted for 50.94% (162/318), 23.58%(75/318), and 17.61% (56/318) respectively.Pseudomonas aeruginosa were susceptible to Amikacin.Ceftazidine and Imipenum. Acinetobacter were susceptible to Imipenum. X. meltophilia were susceptible to TMP/SMZ,Ceftozidne and Ciprofloxacin.Conclusion: Non zymophytes are a major pathogen and their resistance to antibiotic is very serious. The reasonable use of antibiotic is the essential for the prevention and cure of infections resulted from them.