腮腺恶性淋巴上皮病变临床病理分析

Clinicopathologic Analysis of Malignant Lymphoepithelial Lesions of the Parotid Gland

探讨腮腺恶性淋巴上皮病变的临床病理特征、发病机制及鉴别诊断.该病的组织病理学特征为肿瘤细胞呈大小不等的团巢状分布,间质大量淋巴细胞浸润;免疫组化显示细胞角蛋白和上皮膜抗原阳性.该病是一种差分化鳞状细胞癌,好发年龄40～49岁,其形成与EB病毒感染有关.

This paper studies the clinicopathologic characteristics,mechanism and differential diagnoses of malignant lymphoepithelial lesions of the parotid gland.Histologically,this tumor is characterized by the formation of cell nests of variable sizes and marked lymphocytes infiltrating into the stromal tissue.The results of immiunohistochemistry show cy- tokeratin and epithelial membrane antigen are positive.Malignant lymphoepithelial lesions of the parotid gland,which is susceptible to the ages from 40 to 49,is a poorly differentiated squamous carcinoma and relative to ER virus infection.