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细胞间粘附分子-1在细菌性角膜炎角膜组织表达的实验研究 被引量:2

EXPRESSION OF INTERCELLULAR ADHESION MOLECULE-1 IN CORNEA OF RAT WITH BACTERIAL KERATITIS
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摘要 为探讨细胞间粘附分子 1(ICAM 1)在细菌性角膜炎发病机制中的作用 ,笔者研究了大鼠细菌性角膜炎角膜组织ICAM 1的表达及分布。SD大鼠 2 2只随机分为细菌性角膜炎组和对照组。应用抗ICAM 1单克隆抗体及免疫组化染色技术观察角膜上皮细胞、基质层角膜细胞及内皮细胞的特异性染色。结果显示 ,对照组角膜上皮细胞及内皮细胞染色程度为 - + ,基质层角膜细胞染色为 + ;角膜炎组角膜上皮细胞、基质层角膜细胞及内皮细胞染色程度 。细菌性角膜炎组角膜上皮细胞、基质层角膜细胞及内皮细胞ICAM 1的表达较对照组明显增强 (P <0 .0 1)。提示ICAM 1在细菌性角膜炎的炎细胞游走、浸润等病理改变中发挥重要作用。 To investigate the role of intercellular adhesion molecule 1(ICAM 1) in the pathogenesis of bacterial keratitis,22 rats were randomly divided into bacterial keratitis group and control group. A specific staining of corneal epithelial cells, stromal keratocytes and endothelial cells for ICAM 1 was carried out by using monoclonal antibody to ICAM 1 and immunohistochemical staining techniques. The results showed that ICAM 1 expressed a low level in the corneal epithelial cells, stromal keratocytes and endothelial cells in the control group(-^+), while its expression was strong in the keratitis group (~). The difference between two groups was statistically significant ( P <0.01). It suggested that ICAM 1 might play an important role in the migration of inflammatory cells and their infiltration in bacterial keratitis.
出处 《解放军医学杂志》 CAS CSCD 北大核心 2001年第8期585-586,共2页 Medical Journal of Chinese People's Liberation Army
关键词 细胞间粘附分子-1 细菌性角膜炎 免疫组织化学 intercellular adhesion molecule 1 bacterial keratitis immunohistochemical staining
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  • 1张文华,中华眼科杂志,1987年,23卷,72页

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