筋膜间室综合征治疗的实验研究

AN EXPERIMENTAL STUDY ON THE TREATMENT OF COMPARTMENT SYNDROME

应用袖带压迫法建立新的筋膜间室综合征动物模型 ,观察用药前后血CPK、MDA、组织压以及病理学变化 ,研究甘露醇和山莨菪碱对筋膜间室综合征的治疗作用。结果发现 ,治疗组血清酶含量及组织压较对照组下降 (P <0 0 1) ;神经、肌肉组织变性程度减轻、范围缩小。说明本法建立的模型是成功的 ;甘露醇对筋膜间室综合征有明确的治疗作用 ,并可防治缺血再灌注损伤 ;山莨菪碱对改善微循环、减轻肢体肿胀有确切疗效 ;血CPK可做为判断筋膜间室综合征疗效的指标。

In order to determine the efficacy of mannitol and anisodamine in the treatment of compartment syndrome, a new animal model of compartment syndrome was used to observe the changes in CPK, MDA, tissue pressure and pathology before and after the use of the drugs. The results showed that the values of CPK, MDA and intracompartmental pressure declined and pathological changes improved after the therapy. The result indicated that this new animal model is reproducible and successful. Mannitol is useful in the treatment of compartment syndrome, and at the same time it acts as a free radical scavenger, so that it can prevent reperfusion injury. Anisodamine can improve the limb's microcirculation. CPK can be an index for judging the therapeatic effect in the treatnent of compartment syndrome.