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幽门螺杆菌的CagA和VacA的致病机制及其临床意义

Pathogenic mechanism of CagA and VacA produced by Helicobacter pylori and its clinical significance
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摘要 幽门螺杆菌 (Helicobacterpylori,H .pylori)是消化道的主要致病因素之一 ,随着对H .pylori认识的深入 ,人们发现H .pylori的两个标志性毒素———细胞毒素相关蛋白 (cytotoxin associatedprotein ,CagA)和空泡毒素 (vacuolatingcytotoxin ,VacA)不仅关系紧密 ,而且在致病过程中扮演了重要角色。 H.pylori has been idenfied as one of the main pathogenic factors in human digestive tract. CagA and VacA, which are produced by H.pylori, might play important roles in the occurence and development of many digestive diseases. Accordingly, this review is to summarize the pathogensis and significance of CagA and VacA.
作者 梅峰 周志华 凌娜佳 陈维佩
机构地区 第三军医大学学员旅三队
出处 《免疫学杂志》 CAS CSCD 北大核心 2001年第z1期56-59,67,共4页 Immunological Journal
关键词 幽门螺杆菌 毒素 H.pylori cytotoxin
分类号 R378.99 [医药卫生—病原生物学]
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免疫学杂志
2001年 第z1期

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