摘要
利用手性双胺双膦铱配合物为催化剂研究了苯乙酮的不对称氢转移还原反应 ,4 5℃下反应 ,在苯乙酮、铱配合物、氢氧化钾的摩尔比为 50 0 0∶1∶2时 ,仍能得到 51 %的转化率和 6 6 %的ee值 .
The chiral system generated insitu from chiral PNNP ligand and [Ir(COD)Cl] 2 was used in the asymmetric hydrogen-transfer hydrogenation of acetophenone to secondary alcohol, with 51% conversion and 66% enantiomeric excess under 45℃, when the mole ratio of acetophenone, iridium(I) complexes and potassium hydroxide is 5000:1:2; in some cases, up to 80% ee has been obtained. The effect of various reaction conditions on the activity and enantioselectivity had been studied.
出处
《湛江师范学院学报》
2001年第3期12-15,共4页
Journal of Zhanjiang Normal College
关键词
手性铱配合物
催化
苯乙酮
不对称氢化
Asymmetric hydrogenation
Iridium(I) complexes
Acetophenone
