甲硝唑牙用药膜与口服甲硝唑治疗牙周炎对比研究

Evaluation of metronidazole strip and systemic metronidazole in periodontitis

目的 比较甲硝唑牙用药膜和口服甲硝唑治疗牙周炎的疗效和优缺点。方法 3 0例成人牙周炎 ,随机分全身用药组 (S)、局部用药组 (L)和对照组包括机械治疗对照 (ScR)与空白对照 (C) ,评估临床指标及细菌学改变。结果 各组治疗后SBI、厌氧菌总数、专性和廉性厌氧菌比显著减小 (P <0 .0 5或P <0 .0 1) ,L组革兰阴性专厌氧黑色菌和梭杆菌检出率下降 ,较S组明显 (P <0 .0 5 )。结论 甲硝唑牙用药膜较口服甲硝唑有效 。

Objective To compare the effects and the advantages or disadvantages of metronidazole strip with systemic metronidazole in treating adult periodontitis. Method 30 subjects of adult periodontitis patients were selected. The subjects were randomly divided into three groups according to the treatments they received:① Systemic metronidazole treatment (S),② Local metronidazole treatment (L),③ Control group, including scaling and root planing (ScR) and blank control group (C). A microbiogical and clinical evaluation was conducted before and after treatment. Results Significant changes were found in SBI, the total counts of anearobically cultivable bacteria, obligately anaerobic/facultatively anaerobic ratio after treatment ( P <0.05) Significant differences in the detection of obligately anaerobic black bacterium and fusobacterium within the groups before and after treatment were founded in group L. Group L was better than group S. Conclusion Metronidazole strip produced some beneficial beffects on clinical parameters, which are similar to those produced by ScR. Metronidazole strip seems to be more effective than systemic metronidazole.