腮腺恶性淋巴上皮病变(附2例报告)

Malignant lymphoepithelial lesions of the parotid gland

目的 探讨腮腺恶性淋巴上皮病变的临床病理特征、发病机制及鉴别诊断。方法 对 2例腮腺恶性淋巴上皮病变进行病理组织学观察与免疫组化检测 ,并复习文献 3 4例进行讨论。结果 该病的组织病理学特征为肿瘤细胞呈大小不等的团巢状分布 ,间质大量淋巴细胞浸润 ;免疫组化显示细胞角蛋白和上皮膜抗原阳性。结论 腮腺恶性淋巴上皮病变是一种低分化鳞状细胞癌 ,好发年龄 40～ 49岁 。

Purpose To study the clinicopathologic characteristic, mechanism and differential diagnosis of malignant lymphoepithelial lesions of the parotid gland. Methods Two cases of malignant lymphoepithelial lesions of the parotid gland were studied by light microscopy and immunohistochemistry and 34 cases in past literature were reviewed. Results Histologically,this trmor was characterized by the formation of cell nests of variable size and marked lymphocytes infiltrations into the stromal tissue. The results of immiunohistochemistry showed cytokeratin and epithelial membrane antigen positive. Conclusion Malignant lymphoepithelial lesions of th parotid gland, which is susceptible to the ages from 40 to 49, is a poorly differenteated squamous carcinoma and relative to EB virus infection.