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Fhit蛋白表达缺失在胃癌进展中的意义

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摘要   胃癌是我国最常见的恶性肿瘤之一,其发病率逐年上升,严重威胁着患者的生命.其发生系多因素、多阶段、多基因累积的过程,涉及到多个原癌基因的激活和抑癌基因的失活.……
出处 《当代医学》 2008年第3期40-41,共2页 Contemporary Medicine
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参考文献8

  • 1[1]Kawaguchik,Yashinak,Koda M,et al.Fhit expression in human gastric adenomas and intrmucosal carcinomas correlation with Mlhl expression and gastric phenotype.Br J Cancer,2004,90(3):672-677.
  • 2[2]Ohta M,Inous H,Cotticelli MG,et al.The fhit gene spanningthe chromosone 3p14.2 fragile site and renal carcinoma-associated t(3;8]breakpoint,is abnormal in digestive tract cancers.Cell,1996.84(4):587-597.
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二级参考文献22

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  • 3Butler D,Collins C, Mabruk M, et al. Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer. GynecolOncol,2002,86(2):144~9.
  • 4Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 1996, 84(4):587~97.
  • 5Huebner K, Croce CM. FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer, 2001, 1(3):214~21.
  • 6Barnes LD, Garrison PN, Siprashvili Z, et al. Fhit, a putative tumor suppressor in humans, is a dinuclevside 5', 5"-P1, P3-triphosphate hydrolase. Biochemistry, 1996,35(36):11529~35.
  • 7Siprashvili Z, Sozzi G, Barnes LD, et al. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci USA, 1997, 94(25):13771~6.
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  • 9Andachi H, Yashima K, Koda M, et al. Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. Br J Cancer, 2002,87 (4):441~5.
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