706株需氧革兰阴性杆菌耐药性分析

Drug-resistance Analyses on 706 Strains of Gram-negative Aerobic Bacilli

目的了解本院需氧革兰阴性(G-)杆菌菌种分布及耐药情况。方法对2003-2005年分离的需氧革兰阴性杆菌所做的药物敏感试验进行耐药性分析。结果706株需氧G^-杆菌中,构成比例最大的前3种病原菌为大肠埃希氏菌、铜绿假单胞菌和不动杆菌属,分别占革兰阴性杆菌的28.47%(201株)、17.84%(126株)、16.86%(119株);所分离菌种对美洛培南耐药率较低,为15%以下;对氨苄西林耐药率最高,达85%以上;大肠埃希菌产ESBLS的检出率为31.84%,克雷伯菌产ESBLS的检出率为36.99%,且超广谱β-内酰胺酶检出率呈逐年上升趋势。结论需氧G^-杆菌菌种分布以大肠埃希菌为多,耐药菌株有逐年上升的趋势,需引起重视。

Objective To understand the strain distribution and resistant status of Gram-negative aerobic bacilli in our hospital. Methods Resistance analyses were performed on susceptibility test results of Gram-negative aerobic bacilli isolated during 2003-2005. Results Of 706 strains of gram-negative aerobic bacilli, the top three pathogens with the largest constituent ratio were Escherichia coli, Pseudomonas aeruginosa and Acinetobacter in succession, representing 28.47% (201 of 706), 1Z84% (126 of 706) and 16. 86% (119 of 706) respectively. The rate of resistance to imipenem in the strains isolated was lower below 15%, and that to ampiciUin was the highest, amounting to 85% above. The detection rates for ESBLs-producing Escherichia coli and KlebsieUa pneumoniae were 31.84% and 36.99, respectively, showing a tendency to increased detection rate year by year Conclusion Escherichia coli predominated among Gram-negative aerobic bacilli, tending to increase gradually, which should be paid attention.