167例煤工尘肺继发肺部真菌感染临床分析

Clinical study of 167 patients of coal worker's pneumoconiosis with secondary fungal infection

目的探讨煤工尘肺患者继发肺部真菌感染的常见易患因素和对策.方法用回顾性调查的方法分析了167例煤工尘肺继发肺部真菌感染.结果141例患者尚伴有其他基础疾病,长期使用广谱抗生素及糖皮质激素是肺部感染的危险因素,在感染的真菌类型中,念球菌最常见,占97%.特别是白色念珠菌占64.43%.结论长期使用广谱抗生素及糖皮质激素是煤工尘肺患者继发肺部真菌感梁的主要高危因素.避免各种易发因素,积极采取各种防治措施刻不容缓.

Objective To investigate the common risk factors and measures of the coal worker's pneumoconiosis(CWP)with secondary fungal infection.Methods 167 cases of the coal worker' s pneumoconiosis with secondary fungal infection were retrospectively an alyzed.Results 141 cases were accompanied with other predisposing diseases.The major risk factors included long-term use of broad spectrum antibiotics and glucocorticoids.Among the fungal types.Candida spp was the major-pathogens, accounting for 97 percent,especially candida albicans(64.43%).Conclusions The main risk factor for CWP developing secondary fungal infection is long-term use of broad spectrum antibiotics and glucocorticoids.So it is time to avoid the risk factors and to take various effective control means actively.