钛合金表面改性对细菌黏附的影响

Influence of Surface Modification on Titanium Alloy on Adhesion of Bacteria

目的研究钛合金表面改性形成氨化钛膜对细菌黏附能力的影响.方法制作钛合金试件144件,随机选出72件,采用多弧离子镀法在其表面改性形成氨化钛膜,钛合金为对照组,镀膜后钛合金为实验组.在实验组和对照组试件表面黏附血链球菌、黏性放线菌、白色念珠菌,分别进行细菌体外黏附实验.用菌落形成单位计数法统计分析氨化钛膜形成前后各种细菌黏附量的变化.结果在细菌黏附24、48、168h,上述3种细菌在实验组表面黏附量较对照组表面黏附量显著减少(P<0.001).结论钛合金表面改性形成氨化钛膜可抑制细菌黏附.

Objective To study the influence of TiN coat on clinically used titanium alloy on adhesion of bacteria.Methods A hundred and forty-four pieces of titanium alloy were made,and randomly chosen half of thee,and then TiN coating on the surface of them by multi-arc TiN coating technique saved as experimental group,while those of non-coatod,as control.Definite amounts of Strep. sanguis,Actinomyces viscosus,Candida albicans were adhered onto the surfaces of titanium alloy,and then the number of bacteria was assayed by means of clone forming unit (CFU)method at adhesion period 24、48、168h respectively.Results At each period, the number of the adhered Strep.sanguis,Actinomyces viscosus,Candida albicans was significantly reduced in TiN coated titanium alloy group (P<0.001).Conclusion TiN coating may reduce bacterium adhesion on titanium alloy.