吗啡缓释片直肠、口服给药方式在癌痛治疗中的疗效比较

Comparison of Morphine Sustained Release Tablets between Rectal Administration and Oral Administration in Treatment of Cancer Pain

目的比较吗啡缓释片直肠、口服两种给药方式在癌痛控制中的疗效和胃肠道反应情况。方法120名中晚期癌痛患者随机分成4组,每组30人。每组患者给予吗啡缓释片(30~60mg)止痛治疗,每日2次,共4周。OR组第1~2周口服给药,第3~4周直肠给药;RO组第1~2周直肠给药,第3~4周口服给药;OO组第1~4周口服给药;RR组第1~4周直肠给药,观察两种给药方式在癌痛控制中的疗效和胃肠道反应情况。结果吗啡缓释片直肠、口服给药两种方式的镇痛缓解总有效率(RR)分别:OR组77%,RO组80%,OO组82%,RR组77%。直肠给药方式的胃肠道反应情况明显低于口服给药方式。结论吗啡缓释片通过直肠给药可以取得与口服给药一样的镇痛效果,且减少了胃肠道不良反应。

Objective To compare rectal administration with oral administration in the treatment of cancer pain and the side effects.Methods One hundred and twenty patients with cancer pain were randomly divided into 4 groups with 30 patients in each group.The patients were given sustained-release morphine tablets with total dosage of 30～60 mg/d,twice daily.OR group was administered orally in the first two weeks and rectally in the later two weeks;RO group was administered rectally in the first and second weeks,orally ...